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Rajinikanth as Dr. Vaseegaran / Chitti / Kutti |
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Akshay Kumar as Pakshi Rajan |
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Amy Jackson as Nila |
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Sudhanshu Pandey as Dhinendra 'Dhina' Bohra |
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Adil Hussain as Home Minister |
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Kalabhavan Shajon as Vaira Moorthy |
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Kaizaad Kotwal as Ranjeet Lulla |
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Dr. Ishari. K. Ganesh as Jeyanth Kumar |
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Ananth Narayan Mahadevan as Meeting Chairperson |
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Mayilsamy as Minister of Telecommunications' PA |
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Michael Muthu as Police Officer |
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Sanchana Natarajan as One of the students in Dr.Vaseegaran's lab |
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Raveena Ravi as Nila (voice) |
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Savitha Reddy as Sana (voice) |
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Maya S. Krishnan as College Student |
| Production | Dmytro Sukhanov | Co-Executive Producer |
| Sound | Arjun Chandy | Playback Singer |
| Sound | Sid Sriram | Playback Singer |
| Art | T. Muthuraj | Art Direction |
| Production | Rahul Nanda | Publicist |
| Visual Effects | Mahesh Ganguly S | Animation Supervisor |
| Editing | Anthony | Editor |
| Directing | Shankar | Director |
| Sound | Blaaze | Playback Singer |
| Sound | Shashaa Tirupati | Playback Singer |
| Writing | Jeyamohan | Dialogue |
| Writing | Shankar | Screenplay |
| Costume & Make-Up | Alan Lashbrook | Costume Design |
| Camera | Nirav Shah | Director of Photography |
| Sound | A.R. Rahman | Original Music Composer |
| Writing | Shankar | Story |
| Production | Subaskaran Allirajah | Producer |
| Directing | Aran V | Assistant Director |
| Production | Naveen Varadarajan | Line Producer |
| Directing | Mohmmad Yunus Ismail | Assistant Director |
| Art | Jeffrey Henderson | Storyboard Artist |
| Crew | Bosco Martis | Choreographer |
| Production | Sawan Solanki | Production Manager |
| Sound | Resul Pookutty | Sound Designer |
| Production | Tegveer Singh | Production Manager |
| Production | Raju Mahalingam | Producer |
| Production | Chandanraj Parayan | Production Manager |
| Writing | Jeyamohan | Screenplay |
| Costume & Make-Up | Mary E. Vogt | Costume Design |
| Production | Navmeet Singh | Line Producer |
| Writing | Lakshmi Saravanakumar | Dialogue |
| Sound | A. R. Ameen | Playback Singer |
| Sound | Bamba Bakya | Playback Singer |
| Sound | Suzanne D'Mello | Playback Singer |
| Writing | Na. Muthu Kumar | Lyricist |
| Writing | Madhan Karky | Lyricist |
| Crew | Karan Johar | Presenter |
