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Emmanuelle Vaugier as Jane Browning / Painkiller Jane |
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Eric Dane as Nick |
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Richard Roundtree as Colonel Watts |
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Venus Terzo as Carla Browning |
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Walker Howard as Blue |
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Callum Keith Rennie as Mitchell |
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Tate Donovan as Dr. Graham Knight / Lucas Insley |
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Paula Brancati as Young Jane |
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Elicia Mackenzie as Young Carla |
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Martin Cummins as Sergeant Flynn |
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Richard Harmon as Squeak |
| Writing | John Harrison | Writer |
| Costume & Make-Up | Jenni Gullett | Costume Design |
| Costume & Make-Up | Diane Widas | Costume Design |
| Costume & Make-Up | Pearl Louie | Makeup Department Head |
| Art | Doug McLean | Art Direction |
| Production | Harvey Frand | Producer |
| Writing | Don Keith Opper | Writer |
| Editing | Andrew Seklir | Editor |
| Sound | Brian Tyler | Music |
| Art | Richard Hudolin | Production Design |
| Camera | Stephen McNutt | Director of Photography |
| Art | Dominique Fauquet-Lemaitre | Set Decoration |
| Costume & Make-Up | Lisa Love | Makeup Artist |
| Directing | Sanford Bookstaver | Director |
| Crew | Lauro David Chartrand-DelValle | Stunt Coordinator |
| Crew | Melissa R. Stubbs | Stunt Coordinator |
| Crew | Marny Eng | Stunts |
| Crew | Chad Sayn | Stunts |
| Lighting | Don Saari | Gaffer |
| Directing | Colleen Mitchell | Second Assistant Director |
| Art | Ken Rabehl | Assistant Art Director |
