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Kamal Haasan as Govindarajan Ramaswamy / Rangaraja Nambi / George W. Bush / Avtaar Singh / Balram Naidu / Christian Fletcher / Shinghen Narahasi / Krishnaveni / Vincent Poovaragavan / Kalifullah Mukhtaar |
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Asin Thottumkal as Kodhai Radha / Andal |
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Mallika Sherawat as Jasmine |
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Jaya Prada as Ranjitha Singh |
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Napoleon as Kulothunga Chola II |
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P. Vasu as J. Ragavendra (Jaa Raa) |
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Raghuram as Appa Rao |
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Nagesh as Sheikh Mukhtaar |
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Chakri Toleti as Sairam |
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Shammu as Assistant Biotechnologist |
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M. S. Bhaskar as Broadway Kumar |
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Vaiyapuri as Prabhu |
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Chitti Babu as Ekambaram |
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Santhana Bharathi as J. Ragavendra's brother-in-law |
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R. Sundarrajan as Member of Legislative Assembly |
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K R Vijaya as Megha Mukhtaar |
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Ramesh Khanna as Doctor |
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David W. Scott as Lab Tech / Detective |
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Brian Jennings as Chief of Home Land Security |
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Rekha as Meenakshi Ragavendra |
| Sound | Sadhana Sargam | Playback Singer |
| Sound | Devi Sri Prasad | Original Music Composer |
| Writing | Vaali | Lyricist |
| Sound | Hariharan | Playback Singer |
| Sound | Pop Shalini | Playback Singer |
| Sound | Mahalakshmi Iyer | Playback Singer |
| Sound | Himesh Reshammiya | Playback Singer |
| Sound | Kamal Haasan | Playback Singer |
| Writing | Vairamuthu | Lyricist |
| Sound | Himesh Reshammiya | Original Music Composer |
| Editing | Ashmith Kunder | Editor |
| Directing | K. S. Ravikumar | Director |
| Production | V. Ravichandran | Producer |
| Crew | Grady Allen Bishop | Stunt Double |
| Writing | Kamal Haasan | Story |
| Writing | Kamal Haasan | Dialogue |
| Writing | Atul Tiwari | Dialogue |
| Writing | Kamal Haasan | Screenplay |
| Editing | Thanigachalam | Editor |
| Crew | Andrew Scott Dixon | Stunt Coordinator |
| Costume & Make-Up | Michael Mosher | Special Effects Makeup Artist |
| Costume & Make-Up | Ralis Kahn | Special Effects Makeup Artist |
| Costume & Make-Up | Gautami Tadimalla | Costume Design |
| Camera | Ravi Varman | Director of Photography |
| Crew | Kanal Kannan | Stunt Coordinator |
| Art | M. Prabhaharan | Art Direction |
